ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. [electronic resource]
Producer: 20150304Description: 6968-79 p. digitalISSN:- 1538-7445
- Ataxia Telangiectasia Mutated Proteins -- antagonists & inhibitors
- Camptothecin -- analogs & derivatives
- Cell Line, Tumor
- Checkpoint Kinase 1
- DNA Damage
- DNA Replication -- drug effects
- DNA Topoisomerases, Type I -- metabolism
- HT29 Cells
- Histones -- genetics
- Humans
- Irinotecan
- Organothiophosphorus Compounds -- pharmacology
- Phosphorylation -- drug effects
- Protein Kinases -- genetics
- Pyrazines -- pharmacology
- Replication Origin -- drug effects
- Single-Cell Analysis -- methods
- Sulfones -- pharmacology
- Topoisomerase I Inhibitors -- pharmacology
- Topotecan -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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