Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors. [electronic resource]
Producer: 20150117Description: 31513-25 p. digitalISSN:- 1083-351X
- Antineoplastic Agents -- chemistry
- BH3 Interacting Domain Death Agonist Protein -- metabolism
- Binding Sites
- Camptothecin -- chemistry
- Cell Cycle
- Cell Line, Tumor
- Cell Survival
- Checkpoint Kinase 1
- DNA Repair
- Down-Regulation
- Drug Resistance
- Fibroblasts -- metabolism
- Gene Expression Regulation, Neoplastic
- Humans
- Phosphorylation
- Promoter Regions, Genetic
- Protein Kinases -- metabolism
- RNA Interference
- RNA, Small Interfering -- metabolism
- Replication Protein A -- metabolism
- S Phase
- Signal Transduction
- Topoisomerase I Inhibitors -- chemistry
- Transcription Factors -- metabolism
- Zinc Finger Protein GLI1
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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