LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth. [electronic resource]
Producer: 20150728Description: 6059-70 p. digitalISSN:- 1557-3265
- Animals
- Antibodies, Monoclonal -- administration & dosage
- Antibodies, Monoclonal, Humanized -- pharmacology
- Antibodies, Neutralizing -- administration & dosage
- Antineoplastic Agents -- administration & dosage
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Disease Models, Animal
- Down-Regulation
- Enzyme Activation -- drug effects
- Female
- Hepatocyte Growth Factor -- metabolism
- Humans
- Macaca fascicularis
- Male
- Mice
- Neoplasms -- drug therapy
- Phosphorylation
- Protein Transport
- Proteolysis
- Proto-Oncogene Proteins c-met -- antagonists & inhibitors
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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