Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells. [electronic resource]
Producer: 20150622Description: 377-86 p. digitalISSN:- 2211-3436
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Non-Small-Cell Lung -- genetics
- Caspase 8 -- metabolism
- Cell Line, Tumor
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Cytoplasm -- drug effects
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- ErbB Receptors -- antagonists & inhibitors
- Flow Cytometry
- Gefitinib
- Humans
- Lung Neoplasms -- genetics
- Microscopy, Confocal
- Mutation
- Protein Binding -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Protein Transport -- drug effects
- Quinazolines -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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