A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression. [electronic resource]
Producer: 20150804Description: 9838-50 p. digitalISSN:- 1949-2553
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Apoptosis -- drug effects
- Cell Cycle Checkpoints
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Colonic Neoplasms -- blood supply
- Female
- G1 Phase Cell Cycle Checkpoints -- drug effects
- HCT116 Cells
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Hydroxamic Acids -- pharmacology
- Indoles -- pharmacology
- Male
- Mice
- Mice, Nude
- Mice, SCID
- Neovascularization, Pathologic -- drug therapy
- Signal Transduction
- Tissue Inhibitor of Metalloproteinase-3 -- antagonists & inhibitors
- Up-Regulation -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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