Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways. [electronic resource]
Producer: 20150616Description: 671-83 p. digitalISSN:- 1873-5576
- Animals
- Antineoplastic Agents -- administration & dosage
- Body Weight -- drug effects
- Cell Line
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drugs, Investigational -- administration & dosage
- G2 Phase -- drug effects
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Isoxazoles -- administration & dosage
- MAP Kinase Signaling System -- drug effects
- Male
- Mice, Nude
- Molecular Targeted Therapy -- adverse effects
- Neoplasm Proteins -- antagonists & inhibitors
- Pancreatic Neoplasms -- drug therapy
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Pyridones -- administration & dosage
- Random Allocation
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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