Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. [electronic resource]
Producer: 20150107Description: 12328-40 p. digitalISSN:- 1529-2401
- Action Potentials -- genetics
- Amino Acid Sequence
- Animals
- Female
- Ganglia, Spinal -- physiopathology
- HEK293 Cells
- Humans
- Leg
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation -- genetics
- NAV1.7 Voltage-Gated Sodium Channel -- chemistry
- Neural Inhibition -- genetics
- Pain -- physiopathology
- Posterior Horn Cells -- metabolism
- Rats
- Rats, Sprague-Dawley
- Structure-Activity Relationship
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Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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