Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts. [electronic resource]
Producer: 20150129Description: 1029-32 p. digitalISSN:- 1432-0843
- Aminopterin -- administration & dosage
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Body Weight -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Synergism
- Female
- Folic Acid Antagonists -- administration & dosage
- Glutamates -- pharmacology
- Guanine -- analogs & derivatives
- Humans
- Leucovorin -- administration & dosage
- Mesothelioma -- drug therapy
- Methotrexate -- pharmacology
- Mice, Nude
- Pemetrexed
- Time Factors
- Tumor Burden -- drug effects
- Vitamin B Complex -- administration & dosage
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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