TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway. [electronic resource]
Producer: 20141117Description: 352-8 p. digitalISSN:- 1521-0103
- Animals
- Apoptosis -- drug effects
- Autoantigens -- metabolism
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Caspase 3 -- metabolism
- Caspase 9 -- metabolism
- Cell Line, Tumor
- Down-Regulation -- drug effects
- ErbB Receptors -- metabolism
- Erlotinib Hydrochloride
- Humans
- Intracellular Signaling Peptides and Proteins
- Lung Neoplasms -- drug therapy
- Male
- Membrane Proteins -- metabolism
- Mice
- Mice, Nude
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Phosphatase 2 -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Quinazolines -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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