Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation. [electronic resource]
Producer: 20150225Description: 600-7 p. digitalISSN:- 1090-2104
- Cell Line
- Cell Nucleus -- metabolism
- Cytoplasm -- metabolism
- Cytoplasmic Granules -- chemistry
- Gene Expression
- HEK293 Cells
- Heterogeneous Nuclear Ribonucleoprotein A1
- Heterogeneous-Nuclear Ribonucleoprotein Group A-B -- chemistry
- Humans
- Mutation
- Neurons -- chemistry
- Protein Aggregates
- Protein Aggregation, Pathological -- metabolism
- Protein Structure, Tertiary
- RNA, Messenger -- chemistry
- RNA-Binding Protein FUS -- chemistry
- Survival of Motor Neuron 1 Protein -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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