Epigenetic therapy for Friedreich ataxia. [electronic resource]
Producer: 20141211Description: 489-508 p. digitalISSN:- 1531-8249
- Administration, Oral
- Adolescent
- Adult
- Aminocaproates -- pharmacology
- Area Under Curve
- Benzamides -- pharmacology
- Cell Differentiation -- drug effects
- Cell Line, Transformed
- Chromatin Immunoprecipitation
- Cohort Studies
- Cross-Sectional Studies
- DNA Methylation -- drug effects
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Friedreich Ataxia -- drug therapy
- Gene Expression Regulation -- drug effects
- Histone Deacetylase Inhibitors -- therapeutic use
- Humans
- Iron-Binding Proteins -- genetics
- Leukocytes, Mononuclear -- drug effects
- Male
- Membrane Potentials -- drug effects
- Middle Aged
- Nerve Tissue Proteins -- genetics
- Neurons -- drug effects
- Pluripotent Stem Cells
- Trinucleotide Repeat Expansion -- genetics
- Young Adult
- Frataxin
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Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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