VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2. [electronic resource]
Producer: 20150826Description: 3107-19 p. digitalISSN:- 1476-5594
- Animals
- Cell Proliferation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- MCF-7 Cells
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplastic Stem Cells -- drug effects
- Protein Binding -- drug effects
- Proto-Oncogene Proteins c-myc -- genetics
- SOXB1 Transcription Factors -- genetics
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- Up-Regulation -- drug effects
- Vascular Endothelial Growth Factor A -- pharmacology
- Vascular Endothelial Growth Factor Receptor-2 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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