Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. [electronic resource]
Producer: 20150519Description: 1575-85 p. digitalISSN:- 1520-5010
- Alkylation
- Animals
- Catechols -- chemistry
- Cysteine -- analysis
- Epithelial Cells -- cytology
- Zingiber officinale -- chemistry
- Glutamate-Cysteine Ligase -- metabolism
- Glutathione -- metabolism
- HCT116 Cells
- Heme Oxygenase-1 -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins -- chemistry
- Kelch-Like ECH-Associated Protein 1
- Membrane Proteins -- metabolism
- Mice
- Mice, Knockout
- NF-E2-Related Factor 2 -- deficiency
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Reactive Oxygen Species -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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