Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease. [electronic resource]
Producer: 20151102Description: 952-62 p. digitalISSN:- 1948-7193
- Alzheimer Disease -- drug therapy
- Amyloid beta-Peptides -- metabolism
- Animals
- Antioxidants -- chemical synthesis
- Blood-Brain Barrier -- metabolism
- Capillary Permeability
- Cell Line, Tumor
- Cell Survival -- drug effects
- Clioquinol -- analogs & derivatives
- Copper -- toxicity
- Drug Design
- Drug Evaluation, Preclinical
- Humans
- Hydrogen Peroxide -- metabolism
- Membranes, Artificial
- Models, Biological
- Nootropic Agents -- chemical synthesis
- Peptide Fragments -- metabolism
- Protein Multimerization -- drug effects
- Selenium Compounds -- chemical synthesis
- Swine
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Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
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