A new 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) derivative overcomes paclitaxel resistance by inhibiting MAPK signaling and increasing paclitaxel accumulation in breast cancer cells. [electronic resource]
Producer: 20151109Description: e104317 p. digitalISSN:- 1932-6203
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- genetics
- Acetates -- chemical synthesis
- Animals
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Breast Neoplasms -- genetics
- Cell Line, Tumor
- Disease Models, Animal
- Diterpenes -- chemical synthesis
- Drug Resistance, Neoplasm -- genetics
- Drug Synergism
- Female
- Humans
- MAP Kinase Signaling System -- drug effects
- Paclitaxel -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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