SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. [electronic resource]
Producer: 20150410Description: 595-605 p. digitalISSN:- 1476-5586
- Animals
- Apoptosis -- drug effects
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival -- drug effects
- DNA-Binding Proteins -- genetics
- Disease Models, Animal
- Drug Resistance, Neoplasm
- Drug Synergism
- Humans
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- pharmacology
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 -- genetics
- Pyrroles -- pharmacology
- Regulatory Factor X Transcription Factors
- Regulatory Factor X1
- STAT3 Transcription Factor -- metabolism
- Sorafenib
- Transcription Factors -- genetics
- Tumor Stem Cell Assay
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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