The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers. [electronic resource]
Producer: 20151207Description: 1172-80 p. digitalISSN:- 1098-2744
- Adult
- Aged
- Aged, 80 and over
- Animals
- BRCA1 Protein -- metabolism
- Breast -- metabolism
- Breast Neoplasms -- metabolism
- Enhancer of Zeste Homolog 2 Protein
- Female
- Humans
- Jumonji Domain-Containing Histone Demethylases -- metabolism
- Methyltransferases -- metabolism
- Mice
- Middle Aged
- Polycomb Repressive Complex 2 -- metabolism
- Prognosis
- Receptors, Estrogen -- metabolism
- Young Adult
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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