Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia. [electronic resource]
Producer: 20141107Description: 512-6 p. digitalISSN:- 1476-4687
- Animals
- Benzamides -- pharmacology
- Clone Cells -- drug effects
- Diphenylamine -- analogs & derivatives
- Down-Regulation -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Genes, ras -- genetics
- Indazoles -- pharmacology
- Male
- Mice
- Mice, Inbred C57BL
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Phosphoinositide-3 Kinase Inhibitors
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Protein Kinase Inhibitors -- pharmacology
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptor, Notch1 -- chemistry
- Signal Transduction -- drug effects
- Sulfonamides -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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