An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo. [electronic resource]
Producer: 20141112Description: 4080-91 p. digitalISSN:- 1098-5522
- Animals
- Antibodies, Bacterial -- blood
- Antibodies, Neutralizing -- blood
- Antitoxins -- blood
- Bacterial Proteins -- genetics
- Bacterial Toxins -- genetics
- Bacterial Vaccines -- administration & dosage
- Cross Protection
- Electrophoresis
- Enterotoxins -- genetics
- Female
- Injections, Intramuscular
- Macaca mulatta
- Mice
- Mice, Inbred C57BL
- Neutralization Tests
- Recombinant Proteins -- genetics
- Survival Analysis
- Vaccines, DNA -- administration & dosage
- Vaccines, Synthetic -- administration & dosage
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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