Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. [electronic resource]
Producer: 20141010Description: 904-10 p. digitalISSN:- 1546-170X
- Adolescent
- Alkaline Phosphatase -- biosynthesis
- Animals
- Bone Development -- drug effects
- Bone Diseases, Developmental -- genetics
- Bone Morphogenetic Protein 2 -- genetics
- Calcification, Physiologic -- drug effects
- Cells, Cultured
- Child
- Child, Preschool
- Collagen Type I -- biosynthesis
- Collagen Type I, alpha 1 Chain
- Collagen Type II -- genetics
- Diphosphates -- metabolism
- Disease Models, Animal
- Durapatite -- metabolism
- Humans
- Immunoglobulin G -- therapeutic use
- Infant
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mitogen-Activated Protein Kinases -- metabolism
- Neurofibromatosis 1 -- drug therapy
- Neurofibromin 1 -- genetics
- Osteoblasts -- enzymology
- Osteogenesis -- genetics
- Phosphate Transport Proteins -- biosynthesis
- Phosphoric Diester Hydrolases -- biosynthesis
- Pyrophosphatases -- biosynthesis
- Recombinant Fusion Proteins -- therapeutic use
- Sp7 Transcription Factor
- Transcription Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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