Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. [electronic resource]
Producer: 20140902Description: 1429-44 p. digitalISSN:- 1549-5477
- Animals
- Cell Line
- Cells, Cultured
- Cyclin D1 -- genetics
- Forkhead Box Protein O3
- Forkhead Transcription Factors -- metabolism
- Gene Expression Regulation, Neoplastic
- Hydroxylation
- Hypoxia-Inducible Factor-Proline Dioxygenases -- metabolism
- MCF-7 Cells
- Mice
- Protein Binding
- Protein Stability
- Ubiquitin Thiolesterase -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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