Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies. [electronic resource]
Producer: 20150402Description: 398-408 p. digitalISSN:- 1768-3254
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- adverse effects
- Chemistry Techniques, Synthetic
- Cyclooxygenase 2 -- chemistry
- Cyclooxygenase 2 Inhibitors -- adverse effects
- Drug Design
- Humans
- Male
- Molecular Docking Simulation
- Protein Conformation
- Quantitative Structure-Activity Relationship
- Rats
- Stomach Ulcer -- chemically induced
- Substrate Specificity
- Triazoles -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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