Deletion of FoxO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit. [electronic resource]
Producer: 20150330Description: 297-306 p. digitalISSN:- 1095-8584
- Action Potentials -- physiology
- Animals
- Cell Nucleus -- metabolism
- Connexin 43 -- genetics
- Electrocardiography
- Forkhead Box Protein O1
- Forkhead Transcription Factors -- deficiency
- Gene Expression Regulation
- Heart Ventricles -- metabolism
- Humans
- Mice
- Mice, Knockout
- Myocardial Infarction -- genetics
- Myocytes, Cardiac -- metabolism
- NAV1.5 Voltage-Gated Sodium Channel -- genetics
- Patch-Clamp Techniques
- Primary Cell Culture
- Signal Transduction
- Voltage-Gated Sodium Channel beta-3 Subunit -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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