Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. [electronic resource]
Producer: 20161213Description: 500-11 p. digitalISSN:- 1521-0464
- ATP Binding Cassette Transporter, Subfamily B -- antagonists & inhibitors
- Administration, Oral
- Animals
- Antineoplastic Agents, Phytogenic -- administration & dosage
- Biological Availability
- Breast Neoplasms -- drug therapy
- Cell Separation -- methods
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Carriers
- Drug Compounding
- Etoposide -- administration & dosage
- Female
- Flow Cytometry
- Fluorescent Dyes -- metabolism
- Humans
- Inhibitory Concentration 50
- Intestinal Absorption -- drug effects
- Lactic Acid -- chemistry
- MCF-7 Cells
- Male
- Microscopy, Confocal
- Nanoparticles
- Nanotechnology
- Permeability
- Polyglycolic Acid -- chemistry
- Polylactic Acid-Polyglycolic Acid Copolymer
- Polyvinyl Alcohol -- chemistry
- Quercetin -- administration & dosage
- Rats, Wistar
- Rhodamines -- metabolism
- Solubility
- Sonication
- Technology, Pharmaceutical -- methods
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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