Synthesis and evaluation of three structurally related ¹⁸F-labeled orvinols of different intrinsic activities: 6-O-[¹⁸F]fluoroethyl-diprenorphine ([¹⁸F]FDPN), 6-O-[¹⁸F]fluoroethyl-buprenorphine ([¹⁸F]FBPN), and 6-O-[¹⁸F]fluoroethyl-phenethyl-orvinol ([¹⁸F]FPEO). [electronic resource]
Producer: 20140905Description: 5464-9 p. digitalISSN:- 1520-4804
- Animals
- Brain -- diagnostic imaging
- Buprenorphine -- analogs & derivatives
- CHO Cells
- Carbon Radioisotopes
- Cricetulus
- Diprenorphine -- analogs & derivatives
- Fluorine Radioisotopes
- Humans
- Morphinans -- chemical synthesis
- Narcotic Antagonists
- Positron-Emission Tomography
- Radioligand Assay
- Radiopharmaceuticals -- chemical synthesis
- Rats
- Receptors, Opioid -- agonists
- Structure-Activity Relationship
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Publication Type: Journal Article
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