ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer. [electronic resource]
Producer: 20150416Description: 1940-55 p. digitalISSN:- 2211-1247
- ADAM Proteins -- genetics
- ADAM17 Protein
- Animals
- Apoptosis -- drug effects
- Cell Proliferation -- drug effects
- Colorectal Neoplasms -- drug therapy
- Drug Resistance, Neoplasm
- Female
- HCT116 Cells
- Humans
- MAP Kinase Kinase Kinases -- antagonists & inhibitors
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-met -- metabolism
- Proto-Oncogene Proteins p21(ras)
- STAT3 Transcription Factor -- metabolism
- Signal Transduction
- Xenograft Model Antitumor Assays
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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