Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. [electronic resource]
Producer: 20150730Description: e99211 p. digitalISSN:- 1932-6203
- Antineoplastic Agents -- toxicity
- B7-H1 Antigen -- metabolism
- Down-Regulation -- drug effects
- Histocompatibility Antigens Class I -- metabolism
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase -- genetics
- Interferon-gamma -- pharmacology
- Phosphorylation -- drug effects
- Proteasome Endopeptidase Complex -- metabolism
- Protein Stability
- RNA Interference
- RNA, Messenger -- metabolism
- RNA, Small Interfering -- metabolism
- STAT1 Transcription Factor -- antagonists & inhibitors
- T-Lymphocytes -- immunology
- Tumor Cells, Cultured
- Vidarabine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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