Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice. [electronic resource]
Producer: 20150720Description: 459-83 p. digitalISSN:- 1875-8908
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Antigens, CD -- metabolism
- Antigens, Differentiation, Myelomonocytic -- metabolism
- Cerebral Cortex -- metabolism
- Choline O-Acetyltransferase -- metabolism
- Cholinergic Neurons -- pathology
- Cognition Disorders -- complications
- Disease Models, Animal
- Gene Expression Regulation -- drug effects
- Glial Fibrillary Acidic Protein -- metabolism
- Humans
- Isoleucine -- analogs & derivatives
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Morpholines -- pharmacology
- Mutation -- genetics
- NIH 3T3 Cells
- Nerve Degeneration -- drug therapy
- Nerve Tissue Proteins -- chemistry
- Phosphorylation -- drug effects
- Protein Folding -- drug effects
- Receptors, Nerve Growth Factor -- chemistry
- tau Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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