Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity. [electronic resource]
Producer: 20150207Description: 1176-85 p. digitalISSN:- 2768-6698
- Animals
- Arthritis, Experimental -- prevention & control
- Binding Sites -- genetics
- Cell Line
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Cells, Cultured
- Gene Expression -- drug effects
- HEK293 Cells
- Humans
- Intercellular Adhesion Molecule-1 -- genetics
- Intercellular Signaling Peptides and Proteins -- genetics
- Macrophages -- drug effects
- Male
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Transgenic
- Progranulins
- Protein Binding -- drug effects
- Receptors, Tumor Necrosis Factor -- genetics
- Recombinant Proteins -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha -- genetics
- Two-Hybrid System Techniques
- Vascular Cell Adhesion Molecule-1 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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