Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. [electronic resource]
Producer: 20150112Description: 141 p. digitalISSN:- 1476-4598
- Adenocarcinoma -- drug therapy
- Antibodies, Monoclonal, Humanized -- therapeutic use
- Antineoplastic Agents -- therapeutic use
- Cetuximab
- Colorectal Neoplasms -- drug therapy
- Drug Resistance, Neoplasm -- genetics
- ErbB Receptors -- antagonists & inhibitors
- Gene Expression
- High-Throughput Nucleotide Sequencing
- Humans
- Mutation
- Protein Kinase Inhibitors -- therapeutic use
- Protein Multimerization
- Protein Structure, Tertiary
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Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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