Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. [electronic resource]
Producer: 20140905Description: 880-95 p. digitalISSN:- 1097-4180
- Animals
- Antiviral Agents
- Cells, Cultured
- Enzyme Activation -- immunology
- Humans
- I-kappa B Kinase -- immunology
- Interferon Type I -- immunology
- Janus Kinase 1
- Mice
- Phosphorylation -- immunology
- Polyubiquitin -- biosynthesis
- RNA Interference
- RNA, Small Interfering
- STAT1 Transcription Factor -- immunology
- Signal Transduction -- immunology
- Tripartite Motif Proteins
- Ubiquitin-Conjugating Enzymes -- immunology
- Ubiquitin-Protein Ligases -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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