Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. [electronic resource]
Producer: 20140820Description: 4772-95 p. digitalISSN:- 1520-4804
- Aminopyridines -- chemical synthesis
- Animals
- Anti-Bacterial Agents -- chemical synthesis
- Cytochrome P-450 CYP3A
- Cytochrome P-450 CYP3A Inhibitors
- Diterpenes -- chemical synthesis
- Drug Design
- Drug Resistance, Bacterial
- Drug Stability
- Female
- Humans
- Hydrophobic and Hydrophilic Interactions
- In Vitro Techniques
- Male
- Methicillin-Resistant Staphylococcus aureus -- drug effects
- Mice
- Microbial Sensitivity Tests
- Polycyclic Compounds
- Rats
- Rats, Sprague-Dawley
- Solubility
- Staphylococcal Infections -- drug therapy
- Staphylococcus -- drug effects
- Streptococcus -- drug effects
- Structure-Activity Relationship
- Sulfides -- chemical synthesis
- Pleuromutilins
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Publication Type: Journal Article
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