Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. [electronic resource]
Producer: 20151019Description: e96377 p. digitalISSN:- 1932-6203
- Blotting, Western
- Calcineurin Inhibitors -- pharmacology
- Cell Line
- Collagen Type V -- genetics
- Fibroblasts -- drug effects
- Fibrosis -- genetics
- Gene Expression -- drug effects
- Gene Expression Profiling
- Humans
- Hydrogen Peroxide -- metabolism
- Kidney -- metabolism
- NADPH Oxidase 4
- NADPH Oxidases -- genetics
- Oligonucleotide Array Sequence Analysis
- Phosphorylation -- drug effects
- Procollagen -- genetics
- RNA Interference
- Receptors, Transforming Growth Factor beta -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Smad2 Protein -- metabolism
- Tacrolimus -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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