Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. [electronic resource]
Producer: 20150420Description: 999-1008 p. digitalISSN:- 2211-1247
- Adenocarcinoma -- drug therapy
- Adenocarcinoma of Lung
- Afatinib
- Animals
- Antibodies, Monoclonal, Humanized -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Line, Tumor
- Cetuximab
- Drug Resistance, Neoplasm
- ErbB Receptors -- genetics
- Humans
- Lung Neoplasms -- drug therapy
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Mice, Nude
- Mice, Transgenic
- Multiprotein Complexes -- metabolism
- Mutation
- Quinazolines -- administration & dosage
- Random Allocation
- TOR Serine-Threonine Kinases -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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