Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). [electronic resource]
Producer: 20141021Description: e1222 p. digitalISSN:- 2041-4889
- 1-Methyl-4-phenylpyridinium -- toxicity
- Activating Transcription Factor 4 -- genetics
- Adaptation, Physiological
- Adenosine Triphosphate -- metabolism
- Cell Line
- Computational Biology
- Dopaminergic Neurons -- drug effects
- Energy Metabolism -- drug effects
- Gene Expression Profiling -- methods
- Gene Expression Regulation
- Glucose -- metabolism
- Glutathione -- metabolism
- High-Throughput Nucleotide Sequencing
- Humans
- Mass Spectrometry
- Metabolomics -- methods
- Mitochondria -- drug effects
- Neural Stem Cells -- drug effects
- Neurotoxicity Syndromes -- etiology
- Oligonucleotide Array Sequence Analysis
- Oxidative Stress -- drug effects
- Phosphocreatine -- metabolism
- RNA Interference
- Time Factors
- Transcription, Genetic -- drug effects
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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