Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice. [electronic resource]
Producer: 20141203Description: 307-19 p. digitalISSN:- 2326-6074
- Animals
- Antigens, Differentiation -- pharmacology
- Antigens, Neoplasm -- immunology
- Apoptosis -- immunology
- CD24 Antigen -- genetics
- CD4-Positive T-Lymphocytes -- immunology
- CD8-Positive T-Lymphocytes -- drug effects
- Cell Line, Tumor
- Disease Models, Animal
- Fas Ligand Protein -- genetics
- Female
- Humans
- Immunodominant Epitopes -- immunology
- Interferon-gamma -- biosynthesis
- Mice
- Mice, Transgenic
- Neoplasms -- drug therapy
- Receptor, ErbB-2 -- chemistry
- Receptors, TNF-Related Apoptosis-Inducing Ligand -- genetics
- T-Cell Antigen Receptor Specificity -- immunology
- Tumor Escape -- immunology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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