Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. [electronic resource]
Producer: 20141029Description: 367-78 p. digitalISSN:- 1474-9726
- Animals
- Antioxidants -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Respiration -- drug effects
- Cellular Senescence -- drug effects
- DNA Damage
- Down-Regulation -- drug effects
- Energy Metabolism -- drug effects
- Exodeoxyribonucleases -- genetics
- Gene Knockdown Techniques
- Glutathione -- metabolism
- Homeostasis -- drug effects
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Macromolecular Substances -- metabolism
- Mice
- Mitochondria -- drug effects
- Neoplasms -- metabolism
- Niacinamide -- metabolism
- Oxidation-Reduction -- drug effects
- Oxidative Stress -- drug effects
- Reactive Oxygen Species -- metabolism
- RecQ Helicases -- genetics
- Werner Syndrome -- genetics
- Werner Syndrome Helicase
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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