Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. [electronic resource]
Producer: 20150615Description: 967-80 p. digitalISSN:- 1932-7420
- Adaptor Proteins, Signal Transducing -- metabolism
- Adipose Tissue, Brown -- metabolism
- Adipose Tissue, White -- metabolism
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Cells, Cultured
- Cold Temperature
- Cold-Shock Response
- Diabetes Mellitus
- Energy Metabolism -- physiology
- Feedback, Physiological
- GRB10 Adaptor Protein -- biosynthesis
- Insulin Resistance
- Lipolysis -- physiology
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Mice, Knockout
- Multiprotein Complexes -- antagonists & inhibitors
- Obesity
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Protein Binding
- Proto-Oncogene Proteins c-akt
- Receptor, Insulin -- metabolism
- Regulatory-Associated Protein of mTOR
- Signal Transduction -- physiology
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Thermogenesis -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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