Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. [electronic resource]
Producer: 20141006Description: 3456-67 p. digitalISSN:- 1530-6860
- Amino Acid Sequence
- Animals
- Antimicrobial Cationic Peptides -- deficiency
- Arachidonate 5-Lipoxygenase -- metabolism
- Calcium Signaling
- Cathelicidins -- deficiency
- Cells, Cultured
- Eicosanoids -- biosynthesis
- Humans
- Inflammation -- physiopathology
- Leukotriene B4 -- metabolism
- MAP Kinase Signaling System
- Macrophages -- drug effects
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Peritonitis -- chemically induced
- Phospholipases A2, Cytosolic -- metabolism
- Phosphorylation
- Prostaglandin-Endoperoxide Synthases -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein Processing, Post-Translational
- Receptors, Purinergic P2X7 -- physiology
- Recombinant Proteins -- toxicity
- Thromboxane A2 -- metabolism
- Tumor Necrosis Factor-alpha -- toxicity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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