Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors. [electronic resource]
Producer: 20140706Description: 470-9 p. digitalISSN:- 1521-0103
- Alprostadil -- administration & dosage
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- toxicity
- Anti-Ulcer Agents -- administration & dosage
- Cystic Fibrosis Transmembrane Conductance Regulator -- antagonists & inhibitors
- Gastrointestinal Hemorrhage -- chemically induced
- Gastrointestinal Motility -- drug effects
- Intestinal Mucosa -- drug effects
- Intestine, Small -- drug effects
- Lubiprostone
- Male
- Naphthalenes -- pharmacology
- Nitric Oxide Synthase Type II -- biosynthesis
- Phenylbutyrates -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Receptors, Prostaglandin E, EP4 Subtype -- genetics
- Tumor Necrosis Factor-alpha -- biosynthesis
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Publication Type: Journal Article
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