Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase. [electronic resource]
Producer: 20141020Description: 1923-7 p. digitalISSN:- 1464-3405
- Animals
- Antineoplastic Agents -- chemical synthesis
- Crystallography, X-Ray
- Drug Design
- Enzyme Activation -- drug effects
- Humans
- Inhibitory Concentration 50
- Molecular Structure
- Protein Kinase Inhibitors -- chemical synthesis
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Quinazolines -- chemical synthesis
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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