Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. [electronic resource]
Producer: 20150106Description: 208-220 p. digitalISSN:- 1873-4596
- AMP-Activated Protein Kinases -- genetics
- Aging -- metabolism
- Aldehyde Dehydrogenase -- genetics
- Aldehyde Dehydrogenase, Mitochondrial
- Animals
- Apoptosis -- drug effects
- Atrial Remodeling -- genetics
- Benzamides -- pharmacology
- Benzodioxoles -- pharmacology
- Calcium -- metabolism
- Cardiomegaly -- enzymology
- Fibrosis
- Gene Expression Regulation
- Heterocyclic Compounds, 4 or More Rings -- pharmacology
- Ion Channels -- genetics
- Mice
- Mice, Transgenic
- Mitochondria, Heart -- drug effects
- Mitochondrial Proteins -- genetics
- Myocardial Contraction
- Myocardium -- enzymology
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Resveratrol
- Signal Transduction
- Sirtuin 1 -- genetics
- Stilbenes -- pharmacology
- Superoxides -- metabolism
- Transcription Factors -- genetics
- Uncoupling Protein 2
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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