3-Phenylpropanoic acid-based phosphotyrosine (pTyr) mimetics: hit evolution to a novel orally active protein tyrosine phosphatase 1B (PTP1B) inhibitor. [electronic resource]
Producer: 20150221Description: 918-21 p. digitalISSN:- 1860-7187
- Animals
- Biomimetic Materials -- administration & dosage
- Biomimetics
- Blood Glucose -- drug effects
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- administration & dosage
- Humans
- Mice
- Molecular Structure
- Obesity -- drug therapy
- Phenylpropionates -- chemistry
- Phosphotyrosine -- chemistry
- Protein Tyrosine Phosphatase, Non-Receptor Type 1 -- antagonists & inhibitors
- Rats
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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