Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. [electronic resource]
Producer: 20150102Description: 1259-69 p. digitalISSN:- 1538-8514
- ADAMTS Proteins
- Animals
- Antineoplastic Agents -- administration & dosage
- Calcinosis -- drug therapy
- Cell Line, Tumor
- Cell Proliferation
- Chondrosarcoma -- genetics
- Disease Models, Animal
- Extracellular Matrix Proteins -- genetics
- Hedgehog Proteins -- metabolism
- Humans
- Mice
- Receptors, G-Protein-Coupled -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Smoothened Receptor
- Tumor Burden -- drug effects
- Veratrum Alkaloids -- administration & dosage
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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