Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway. [electronic resource]
Producer: 20141215Description: 855-80 p. digitalISSN:- 1098-1136
- Animals
- Apoptosis Inducing Factor -- antagonists & inhibitors
- Astrocytes -- drug effects
- BH3 Interacting Domain Death Agonist Protein -- antagonists & inhibitors
- Brain Ischemia -- metabolism
- Cathepsin B -- antagonists & inhibitors
- Cathepsin L -- antagonists & inhibitors
- Cells, Cultured
- Cysteine -- antagonists & inhibitors
- Epoxy Compounds -- pharmacology
- Male
- Neuroprotective Agents -- pharmacology
- Pyridines -- pharmacology
- Rats
- Rats, Sprague-Dawley
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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