Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. [electronic resource]
Producer: 20141020Description: 378-86 p. digitalISSN:- 1347-5215
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Aspergillus fumigatus
- Ataxia Telangiectasia Mutated Proteins -- metabolism
- Biological Products -- pharmacology
- Caspase 1 -- metabolism
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Checkpoint Kinase 1
- Checkpoint Kinase 2 -- metabolism
- DNA Damage
- Diketopiperazines -- pharmacology
- Endodeoxyribonucleases -- metabolism
- Heterografts
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phosphorylation
- Prostatic Neoplasms -- drug therapy
- Protein Kinases -- metabolism
- Sphingomonas
- Tumor Suppressor p53-Binding Protein 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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