Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. [electronic resource]
Producer: 20140428Description: 738-51 p. digitalISSN:- 1097-4164
- Adenosine Triphosphate -- chemistry
- Amino Acid Sequence
- Animals
- Binding Sites
- Crystallography, X-Ray
- Gene Expression Regulation, Enzymologic
- Humans
- Insecta
- Ligands
- Mass Spectrometry
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-ret -- chemistry
- Recombinant Proteins -- chemistry
- Sequence Homology, Amino Acid
- Substrate Specificity
- Time Factors
- Tyrosine -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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