A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. [electronic resource]
Producer: 20141021Description: e1079 p. digitalISSN:- 2041-4889
- Active Transport, Cell Nucleus -- drug effects
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Female
- HEK293 Cells
- Humans
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Mice
- Mice, Nude
- Mutation
- Neuroblastoma -- drug therapy
- Protein Kinase Inhibitors -- pharmacology
- Signal Transduction -- drug effects
- Time Factors
- Transfection
- Tumor Burden -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Ubiquitin-Conjugating Enzymes -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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