Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing β-catenin signaling. [electronic resource]
Producer: 20150102Description: 1217-30 p. digitalISSN:- 1538-8514
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Cell Line
- Cell Proliferation
- Cytochromes c -- metabolism
- Disease Models, Animal
- Drug Resistance
- Gene Expression Regulation -- drug effects
- Gene Silencing
- Humans
- Imidazoles -- pharmacology
- Male
- Mast Cells -- drug effects
- Mastocytosis -- genetics
- Mice
- Myeloid Cell Leukemia Sequence 1 Protein -- genetics
- Phosphorylation -- drug effects
- Point Mutation
- Protein Binding
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-kit -- genetics
- Pyridazines -- pharmacology
- Signal Transduction
- TCF Transcription Factors -- metabolism
- Wnt Signaling Pathway -- drug effects
- Xenograft Model Antitumor Assays
- beta Catenin -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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