GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. [electronic resource]
Producer: 20141126Description: 1259-67 p. digitalISSN:- 1791-2423
- Animals
- Apoptosis -- drug effects
- Carcinoma, Hepatocellular -- drug therapy
- Caspase 3 -- metabolism
- Caspase 9 -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Down-Regulation
- Hep G2 Cells
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- biosynthesis
- Interleukin-6 -- metabolism
- Janus Kinase 2 -- metabolism
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Morpholines -- pharmacology
- Neovascularization, Pathologic -- drug therapy
- Organothiophosphorus Compounds -- pharmacology
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- S Phase Cell Cycle Checkpoints -- drug effects
- STAT3 Transcription Factor -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Vascular Endothelial Growth Factor A -- biosynthesis
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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